Skip to content
NOWCAST NewsCenter 5 at 11
Watch on Demand
Advertisement

New drug tested in Boston offers room to breathe for patients with deadly lung disease

Tufts researchers tested Winrevair to treat PAH

New drug tested in Boston offers room to breathe for patients with deadly lung disease

Tufts researchers tested Winrevair to treat PAH

KIDS. I WAS PLAYING BASKETBALL AND I WAS BICYCLING AND DOING ALL THE THINGS I WANTED TO DO WHEN SUDDENLY I COULDN’T. DIAGNOSED WITH PULMONARY ARTERIAL HYPERTENSION OR PAH MIKE BENNETT LEARNED HE WAS LOSING ROOM TO BREATHE. AND YOU KNOW, MY CONDITION WAS GETTING WORSE AS MIKE QUICKLY DISCOVERED PA CAUSES BLOOD VESSELS IN THE LUNGS TO BECOME NARROWER, BLOCKED, OR DESTROYED. THE DAMAGE SHOWS THE BLOOD FLOW, FORCING THE HEART TO WORK EVEN HARDER. THEY GAVE ME THREE YEARS TO LIVE WITHOUT THAT SEVERE MEDICAL INTERVENTION, AND AT THE TIME THAT WAS A LUNG TRANSPLANT OR A HEART LUNG TRANSPLANT. BUT SO FAR, MIKE HASN’T DONE EITHER. INSTEAD, HE’S MOVED FROM ONE MEDICATION TO ANOTHER OVER THE PAST 25 YEARS, ALWAYS PUSHING TO BE PART OF THE NEXT CLINICAL TRIAL. PSYCHOLOGICALLY, FOR ME, IT WAS IMPORTANT TO GET A NEW DRUG BECAUSE I JUST NEEDED HOPE. I NEEDED TO KNOW THAT THERE WAS SOMETHING ELSE OUT THERE. THAT’S WHEN THE FATHER OF FOUR JOINED A LOCAL TRIAL FOR SOTATERCEPT, RECENTLY APPROVED BY THE FDA. IT’S DESIGNED TO CAPTURE PROTEINS IN THE BLOODSTREAM THAT CAUSE HIS BLOOD VESSELS TO NARROW IT DOWN, DIMINISHES THIS GROWTH KIND OF LIKE IF YOU THINK OF A CANDLE AYER OR A TUMOR THAT GROWS AND YOU FIND AN AGENT THAT SUPPRESSES THIS GROWTH, THIS IS THE SAME TYPE OF EFFECT THAT SOTATERCEPT HAS ON THE BLOOD VESSELS IN THE LUNGS. IN PH PATIENTS. DOCTOR IONA PRESTON IS THE DIRECTOR OF PULMONARY HYPERTENSION CENTER AT TUFTS MEDICAL CENTER. SHE ALSO WORKED WITH MERCK TO HELP DEVELOP THE DRUG FOR HER PATIENTS, INCLUDING MIKE. HE IMPROVED HIS ABILITY TO FUNCTION IN AT HOME IN HIS FAMILY. HE AT WORK. HE HAD MORE STAMINA. TODAY, MIKE ADMINISTERS A SHOT OF SOTATERCEPT HIMSELF ONCE EVERY THREE WEEKS WITH THE NEW MEDICATION NOW MARKETED AS LYNN REVERE. HE’S BEEN ABLE TO DISCONTINUE AN IV TREATMENT, WHICH MEANS DAD NO LONGER HAS TO WEAR A CATHETER IN HIS CHEST THAT COULDN’T GET WET. HERE HE IS, SURPRISING HIS BOYS LAST YEAR BY SWIMMING WITH THEM FOR THE. FIRST TIME. MIKE TELLS HIS SHOCKED SON HE’S GOING TO BE OKAY. I HAVE THE ABILITY TO PARTICIPATE IN ACTIVITIES THAT I HAVEN’T BEEN ABLE TO DO IN EIGHT YEARS, AND AND THAT WAS A SEA CHANGE FOR ME. THAT’S A SPECIAL MOMENT, RIGHT THERE. YOU CAN SEE THE IMPROVEMENTS TO MIKE’S QUALITY OF LIFE, BUT DOCTOR PRESTON SAYS SH
Advertisement
New drug tested in Boston offers room to breathe for patients with deadly lung disease

Tufts researchers tested Winrevair to treat PAH

The U.S. Food and Drug Administration recently approved a breakthrough treatment, which was tested in Boston, for people with a rare but often deadly lung disease called pulmonary arterial hypertension.Like many patients, Mike Bennett said the drug has already had a dramatic impact on his life.Diagnosed with PAH more than two decades ago, he remembers when he felt the first symptoms."I was playing basketball and I was bicycling and doing all the things I wanted to do when, suddenly, I couldn't," he said. "And my condition was getting worse."As Bennett quickly discovered, PAH causes blood vessels in the lungs to become narrower, blocked or destroyed.The damage slows blood flow, forcing the heart to work even harder."They gave me three years to live without severe medical intervention," Bennett said. "At the time, that was a lung transplant or a heart-lung transplant."But so far, Bennett has avoided both.Instead, he's moved from one medication to another over the past 25 years.He said he was always pushing to be part of the next clinical trial."Psychologically for me, it was important to get a new drug because I just needed hope," Bennett said. "I needed to know that there was something else out there."That's when the father of four joined a local trial for Sotatercept.    Recently approved by the FDA, the drug is designed to capture proteins in the bloodstream that cause blood vessels to narrow."It diminishes this growth," said Dr. Ioana Preston, director of the Pulmonary Hypertension Center at Tufts Medical Center. "Kind of like, if you think of a cancer or a tumor that grows, and you find an agent that suppresses this growth. This is the same type of effect that Sotatercept has on the blood vessels in the lungs."Preston worked with the pharmaceutical giant Merck to help develop the drug for her patients, including Bennett."He improved his ability to function at home, in his family, at work," Preston said. "He had more stamina."Today, Bennett administers a shot of Sotatercept himself, once every three weeks.With the new medication, which is now marketed as Winrevair, Bennett said he's been able to discontinue an intravenous treatment. The switch means "Dad" no longer has to wear a catheter in his chest that can't get wet.He surprised his two youngest sons last year by swimming with them for the first time."I have the ability to participate in activities that I haven't been able to do in years," Bennett said. "And that was a sea change for me."

The U.S. Food and Drug Administration recently approved a breakthrough treatment, which was tested in Boston, for people with a rare but often deadly lung disease called pulmonary arterial hypertension.

Like many patients, Mike Bennett said the drug has already had a dramatic impact on his life.

Advertisement

Diagnosed with PAH more than two decades ago, he remembers when he felt the first symptoms.

"I was playing basketball and I was bicycling and doing all the things I wanted to do when, suddenly, I couldn't," he said. "And my condition was getting worse."

As Bennett quickly discovered, PAH causes blood vessels in the lungs to become narrower, blocked or destroyed.

The damage slows blood flow, forcing the heart to work even harder.

"They gave me three years to live without severe medical intervention," Bennett said. "At the time, that was a lung transplant or a heart-lung transplant."

But so far, Bennett has avoided both.

Instead, he's moved from one medication to another over the past 25 years.

He said he was always pushing to be part of the next clinical trial.

"Psychologically for me, it was important to get a new drug because I just needed hope," Bennett said. "I needed to know that there was something else out there."

That's when the father of four joined a local trial for Sotatercept.    

Recently approved by the FDA, the drug is designed to capture proteins in the bloodstream that cause blood vessels to narrow.

"It diminishes this growth," said Dr. Ioana Preston, director of the Pulmonary Hypertension Center at Tufts Medical Center. "Kind of like, if you think of a cancer or a tumor that grows, and you find an agent that suppresses this growth. This is the same type of effect that Sotatercept has on the blood vessels in the lungs."

Preston worked with the pharmaceutical giant Merck to help develop the drug for her patients, including Bennett.

"He improved his ability to function at home, in his family, at work," Preston said. "He had more stamina."

Today, Bennett administers a shot of Sotatercept himself, once every three weeks.

With the new medication, which is now marketed as Winrevair, Bennett said he's been able to discontinue an intravenous treatment. The switch means "Dad" no longer has to wear a catheter in his chest that can't get wet.

He surprised his two youngest sons last year by swimming with them for the first time.

"I have the ability to participate in activities that I haven't been able to do in years," Bennett said. "And that was a sea change for me."