| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Geno Smith |
1. Geno Smith, QB | SEA | W 23-20 at NE | 33 | 44 | 327 | 1 | 0 | 3 | 0 | 103.1 |
| 2. Brock Purdy, QB | SF | L 23-17 at MIN | 28 | 36 | 319 | 1 | 1 | 6 | 1 | 101.3 | |
| 3. Jared Goff, QB | DET | L 20-16 vs. TB | 34 | 55 | 307 | 0 | 2 | 0 | 0 | 61.7 | |
| 4. Dak Prescott, QB | DAL | L 44-19 vs. NO | 27 | 39 | 293 | 1 | 2 | 3 | 0 | 78.3 | |
| 5. Gardner Minshew, QB | LV | W 26-23 at BAL | 30 | 38 | 276 | 1 | 1 | 5 | 0 | 94.7 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Josh Jacobs |
1. Josh Jacobs, RB | GB | W 16-10 vs. IND | 32 | 151 | 4.7 | 0 | 34 | 1 | |
| 2. Brian Robinson Jr., RB | WSH | W 21-18 vs. NYG | 17 | 133 | 7.8 | 0 | 40 | 0 | ||
| 3. J.K. Dobbins, RB | LAC | W 26-3 at CAR | 17 | 131 | 7.7 | 1 | 43 | 0 | ||
| 4. James Conner, RB | ARI | W 41-10 vs. LAR | 21 | 122 | 5.8 | 1 | 22 | 0 | ||
| 5. Alvin Kamara, RB | NO | W 44-19 at DAL | 20 | 115 | 5.8 | 3 | 15 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Nico Collins |
1. Nico Collins, WR | HOU | W 19-13 vs. CHI | 8 | 135 | 16.9 | 1 | 28 | 0 | |
| 2. Justin Jefferson, WR | MIN | W 23-17 vs. SF | 4 | 133 | 33.3 | 1 | 97 | 0 | ||
| 3. Marvin Harrison Jr., WR | ARI | W 41-10 vs. LAR | 4 | 130 | 32.5 | 2 | 60 | 0 | ||
| 4. DK Metcalf, WR | SEA | W 23-20 at NE | 10 | 129 | 12.9 | 1 | 56 | 0 | ||
| 5. Malik Nabers, WR | NYG | L 21-18 at WSH | 10 | 127 | 12.7 | 1 | 28 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Germaine Pratt |
1. Germaine Pratt, LB | CIN | L 26-25 at KC | 7 | 9 | 16 | 0.0 | 1 | 0 | 0 |
| 2. Nick Cross, S | IND | L 16-10 at GB | 10 | 5 | 15 | 0.0 | 0 | 0 | 0 | |
| 3. Shaq Thompson, LB | CAR | L 26-3 vs. LAC | 8 | 6 | 14 | 0.0 | 0 | 0 | 0 | |
| 4. Henry To'oTo'o, LB | HOU | W 19-13 vs. CHI | 9 | 4 | 13 | 1.0 | 0 | 0 | 0 | |
| 5. Micah McFadden, LB | NYG | L 21-18 at WSH | 8 | 5 | 13 | 1.0 | 0 | 0 | 0 | |