| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Dak Prescott |
1. Dak Prescott, QB | DAL | L 28-25 vs. BAL | 28 | 51 | 379 | 2 | 0 | 3 | 0 | 91.9 |
| 2. Caleb Williams, QB | CHI | L 21-16 at IND | 33 | 52 | 363 | 2 | 2 | 4 | 1 | 80.8 | |
| 3. Joe Burrow, QB | CIN | L 38-33 vs. WSH | 29 | 38 | 324 | 3 | 0 | 2 | 0 | 127.5 | |
| 4. Andy Dalton, QB | CAR | W 36-22 at LV | 26 | 37 | 319 | 3 | 0 | 2 | 0 | 123.6 | |
| 5. Jalen Hurts, QB | PHI | W 15-12 at NO | 29 | 38 | 311 | 0 | 1 | 4 | 1 | 88.8 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Derrick Henry |
1. Derrick Henry, RB | BAL | W 28-25 at DAL | 25 | 151 | 6.0 | 2 | 29 | 0 | |
| 2. Saquon Barkley, RB | PHI | W 15-12 at NO | 17 | 147 | 8.6 | 2 | 65 | 0 | ||
| 3. Chuba Hubbard, RB | CAR | W 36-22 at LV | 21 | 114 | 5.4 | 0 | 14 | 0 | ||
| 4. Jonathan Taylor, RB | IND | W 21-16 vs. CHI | 23 | 110 | 4.8 | 2 | 29 | 0 | ||
| 5. David Montgomery, RB | DET | W 20-13 at ARI | 23 | 105 | 4.6 | 1 | 16 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Jauan Jennings |
1. Jauan Jennings, WR | SF | L 27-24 at LAR | 11 | 175 | 15.9 | 3 | 34 | 0 | |
| 2. Dallas Goedert, TE | PHI | W 15-12 at NO | 10 | 170 | 17.0 | 0 | 61 | 0 | ||
| 3. Diontae Johnson, WR | CAR | W 36-22 at LV | 8 | 122 | 15.3 | 1 | 35 | 0 | ||
| 4. Ja'Marr Chase, WR | CIN | L 38-33 vs. WSH | 6 | 118 | 19.7 | 2 | 41 | 0 | ||
| 5. Rome Odunze, WR | CHI | L 21-16 at IND | 6 | 112 | 18.7 | 1 | 47 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Zaire Franklin |
1. Zaire Franklin, LB | IND | W 21-16 vs. CHI | 5 | 10 | 15 | 0.0 | 0 | 0 | 0 |
| 2. Ernest Jones IV, LB | TEN | L 30-14 vs. GB | 10 | 3 | 13 | 0.0 | 0 | 0 | 0 | |
| 3. Jamel Dean, CB | TB | L 26-7 vs. DEN | 9 | 4 | 13 | 0.0 | 0 | 0 | 0 | |
| 4. Zack Baun, LB | PHI | W 15-12 at NO | 9 | 4 | 13 | 0.0 | 0 | 0 | 0 | |
| 5. Daiyan Henley, LB | LAC | L 20-10 at PIT | 9 | 3 | 12 | 0.0 | 0 | 0 | 0 | |